Zinc finger and SCAN domain-containing protein 22 (ZSCAN22)

Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) is a nuclear, DNA-binding protein that functions as a transcription factor, containing both a C2H2-type zinc finger domain (for sequence-specific DNA binding) and a highly conserved SCAN domain (for protein-protein interaction and oligomerization)[1][2][4][5][6][7]. ZSCAN22, like other ZSCAN family members, may regulate transcription by binding specific promoter elements and forming complexes with other SCAN domain proteins[1][3][5][7]. It is predicted to play roles in regulating gene expression by RNA polymerase II, potentially impacting multiple biological processes including cell differentiation, apoptosis, and proliferation, with emerging evidence for its involvement in cancer progression due to the broader roles of the ZSCAN protein family, though direct therapeutic targeting and disease associations for ZSCAN22 specifically are currently limited[1][5][7]. No approved drugs, established clinical biomarkers, or notable safety concerns are associated with ZSCAN22 as of present knowledge[5].

Other names

Zinc finger and SCAN domain containing 22HKR2ZNF50Krueppel-related zinc finger protein 2Protein HKR2Zinc finger protein 50oncogene HKR2GLI-Kruppel family member HKR2krueppel-related zinc finger protein 2