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Target intelligence / Profile preview
Zinc finger and SCAN domain-containing protein 31 (ZSCAN31)
- Target
- ZSCAN31
- Molecular classification
- Transcription factor, C2H2 zinc finger protein
01
Overview
Zinc finger and SCAN domain-containing protein 31 (ZSCAN31) is a protein encoded by the ZSCAN31 gene, featuring multiple C2H2-type zinc finger motifs and a SCAN domain, which facilitate DNA binding and protein-protein interactions, respectively. ZSCAN31 functions as a transcription factor, modulating gene expression especially during embryonic development. It has been implicated in tumorigenesis, notably in hepatocellular carcinoma (HCC), where its overexpression correlates with poor patient prognosis and may serve as a biomarker for disease severity. The precise mechanisms by which ZSCAN31 influences cancer biology are under investigation, but it is thought to operate via transcriptional regulation mediated by its zinc finger and SCAN domains, possibly affecting cell proliferation, differentiation, and survival.
- Other names
- ZSCAN31ZNF323Zinc finger protein 323ZNF310PZNF20-LpZinc finger and SCAN domain-containing protein 31
02
Biological functions
Transcriptional regulationEmbryonic organ developmentModulation of gene expressionPossible involvement in cell proliferation, differentiation, and apoptosis
03
Disease associations
Cancer (especially hepatocellular carcinoma, HCC)Possible roles in other tumor types (prognostic factor in cancer progression, e.g., poor survival in HCC patients)
04
Safety considerations
No specific safety concerns reported; as a transcription factor, targeting ZSCAN31 could pose challenges typical of nuclear proteins and transcriptional regulators
05
Biomarkers
ZSCAN31 expression (prognostic biomarker for poor overall survival in HCC)
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