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Target intelligence / Profile preview
Zinc Finger and SCAN Domain Containing Protein 4 (ZSCAN4)
- Target
- ZSCAN4
- Molecular classification
- Transcription factor, Zinc finger protein, SCAN domain protein
01
Overview
ZSCAN4 is a zinc finger transcription factor containing a SCAN domain, crucial for telomere maintenance and genomic stability, particularly in embryonic stem cells. It functions as an embryonic stem cell-specific transcription factor required to regulate ES cell pluripotency. The SCAN domain mediates self-association and association with other SCAN domain proteins. ZSCAN4 binds to telomeres to maintain their length and stability, preventing cellular senescence. Its dysregulation could potentially contribute to genomic instability, a hallmark of cancer and other diseases. It is expressed in embryonic stem cells and preimplantation embryos.
- Other names
- SRE-ZBPCTfin51AW-1 (ZNF174)Number 18 cDNA (ZnF20)
02
Biological functions
Telomere maintenanceRegulation of embryonic stem cell pluripotencyGenomic stabilityTranscription regulation
03
Disease associations
Cancer (potential role in genomic instability)Genetic disorders (potential role due to genomic instability)
04
Safety considerations
Potential for off-target effects due to DNA-binding propertiesDysregulation may lead to genomic instability
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