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Zinc-finger antiviral protein (ZAP)
- Target
- ZAP
- Molecular classification
- Other (restriction factor)
01
Overview
The zinc-finger antiviral protein (ZAP) is a restriction factor that inhibits the replication of RNA and DNA viruses by binding to viral RNA rich in CpG dinucleotides. It promotes the degradation of viral RNA and inhibits translation, often synergizing with other immune pathways. ZAP interacts with cofactors like TRIM25 and KHNYN to enhance its antiviral activity. This protein is involved in the innate immune response, specifically targeting viral RNA for degradation and inhibiting its translation, making it a potential therapeutic target for antiviral strategies.
- Other names
- ZC3HAV1
02
Mechanism of action
RNA degradation, Translation inhibition, Protein ubiquitination
03
Biological functions
Immune responseRNA degradationTranslation inhibitionProtein ubiquitination
04
Disease associations
Infection
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