Zinc finger B-box domain-containing protein 1 (ZBBX)

Zinc finger B-box domain-containing protein 1 (ZBBX) is a protein encoded in humans by the ZBBX gene[4][6]. Its defining feature is the B-box-type zinc finger domain, a structural motif that typically binds two zinc ions and is involved in protein–protein interactions, rather than direct DNA interaction, unlike some other zinc finger proteins[1][2][3][6]. B-box domains are found in a wide variety of proteins, including many transcription factors and structural regulators, but ZBBX itself has not been specifically classified as a receptor, enzyme, transporter, or established therapeutic target[4][6]. Though some zinc finger B-box domain proteins play major regulatory roles, direct involvement of ZBBX in signaling pathways or as a clinical drug target has not been established. An association with "polyneuropathy due to drug" is reported as a disease link, but the details and strength of this association remain unspecified[4]. No curated drugs, biomarkers, or mechanism-of-action data for ZBBX in disease or therapy are available as of now.

Other names

Zinc finger B-Box domain containingZBBXFLJ23049Zbbx