Zinc finger BED domain-containing protein 1 (ZBED1)

Zinc finger BED domain-containing protein 1 (ZBED1) is a nuclear DNA-binding protein encoded by the ZBED1 gene, located in the pseudoautosomal region of the X and Y chromosomes in humans[1][2][3]. It is a transcription factor containing a BED-type zinc finger domain, closely related to the Drosophila DREF protein, and functions primarily to regulate the transcription of genes involved in cell proliferation, chromatin remodeling, and protein metabolism. ZBED1 acts in part by binding specific DNA motifs in gene promoters, such as those of histone H1 and ribosomal protein genes, and can function as an E3 SUMO-protein ligase, modulating chromatin-associated factors like CHD3/Mi2-alpha to positively regulate transcription[2][3]. Aberrant function or expression of ZBED1 has been linked to diseases associated with proliferation and development, including various cancers, Sotos syndrome, and fibrosclerosis of the breast. Despite its clear regulatory roles in cell proliferation, ZBED1 is not yet targeted by any approved drugs and is not currently used as a biomarker, though its functions make it a putative target for therapeutic modulation in proliferative diseases[1][2][3].

Other names

DREFhDREFALTETRAMPKIAA0785DNA replication-related element-binding factorAc-like transposable elementdREF homologE3 SUMO-protein ligase ZBED1BED-type zinc finger domain-containing protein 1