Zinc finger C2HC-type containing protein 1C (ZC2HC1C)

Zinc finger C2HC-type containing protein 1C (ZC2HC1C) is a protein-coding gene most abundantly expressed in testicular tissue and secondarily in specific brain regions, including the choroid plexus and midbrain. The protein contains a non-classical zinc finger domain (C2HC/C3H-type), which is distinct from the more common C2H2-type, and is believed to bind metal ions, particularly zinc. ZC2HC1C has been implicated in the regulation of gene expression, primary cilia development, and is suggested to operate in gene regulatory roles by analogy to other zinc finger proteins. Mutations in ZC2HC1C have been reported as possibly pathogenic in autism spectrum disorder through loss of function in neuronal tissues and may affect primary cilia development, a process linked to several neurodevelopmental conditions. While its function is still being elucidated, studies suggest ZC2HC1C has significant protein-protein interactions in ciliary transport processes, and its dysfunction may contribute to neurodevelopmental pathologies. However, it is not currently recognized as a therapeutic target, and there are no known drugs, biomarkers, or safety concerns directly associated with ZC2HC1C.

Other names

C14orf140FAM164Cfamily with sequence similarity 164, member Cprotein FAM164Czinc finger C2HC domain-containing protein 1C

Not applicable (no drugs known to target this molecule)