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Target intelligence / Profile preview
Zinc finger CCCH domain-containing protein 10 (ZC3H10)
- Target
- ZC3H10
- Molecular classification
- Transcription factor, RNA-binding protein, Other
01
Overview
Zinc finger CCCH domain-containing protein 10 (ZC3H10) is a transcription factor and RNA-binding protein that acts as a specific regulator of microRNA (miRNA) biogenesis, particularly by binding to and negatively regulating the processing of pri-miR-143 through its C3H1-type zinc finger domains[4][5]. ZC3H10 is primarily localized in the nucleus and is involved in post-transcriptional gene regulation. Additionally, ZC3H10 has been shown to act as a novel regulator of mitochondrial function, enhancing mitochondrial biogenesis and activity during myoblast differentiation, and its depletion leads to mitochondrial electron transport chain defects and altered cellular metabolism[3]. There is no current evidence for direct drug interactions or widespread recognition as a therapeutic target, but alterations in its function are associated with metabolic abnormalities, and it may play indirect roles in human disease mechanisms[3][5].
- Other names
- ZC3HDC10FLJ14451zinc finger CCCH-type containing 10zinc finger CCCH domain-containing protein 10
02
Biological functions
Negative regulation of microRNA processingPost-transcriptional regulation of gene expressionRegulation of mitochondrial functionRegulation of myoblast differentiation
03
Disease associations
Other (no strong evidence as a therapeutic target in specific diseases, but potentially implicated in metabolic abnormalities[3])
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