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Target intelligence / Profile preview
Zinc finger CCCH domain-containing protein 18 (ZC3H18)
- Target
- ZC3H18
- Molecular classification
- Other (CCCH-type zinc finger protein family), RNA-binding protein, Nuclear protein
01
Overview
Zinc finger CCCH domain-containing protein 18 (ZC3H18) is a nuclear CCCH-type zinc finger protein that participates in multiple aspects of RNA metabolism. It binds to the mRNA cap binding complex and acts as a protein-macromolecule adaptor. ZC3H18 is thought to contribute to the destabilization of RNA and is predominantly found in nuclear speckles. While many CCCH-type zinc finger proteins are involved in immune responses and viral regulation, ZC3H18 specifically has not been implicated directly in these disease contexts. It appears to play a general role in the regulation of RNA within the nucleus, including potentially influencing RNA splicing and export. There is currently no evidence that ZC3H18 is a direct drug target or therapeutic biomarker.
- Other names
- NHN1Nuclear protein NHN1conserved nuclear protein NHN1ZC3H18zinc finger CCCH-type containing 18
02
Biological functions
mRNA cap binding complex bindingProtein-macromolecule adaptor activityRNA destabilizationRegulation of RNA metabolism (including splicing, nuclear export, polyadenylation)
03
Disease associations
Other (No direct link to specific diseases such as cancer, infection, etc. reported for ZC3H18 specifically; broader CCCH-type zinc finger family members are implicated in inflammation, immune response, and antiviral actions, but not ZC3H18 itself)
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