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Target intelligence / Profile preview
Zinc finger CCCH-type containing 11B (ZC3H11B)
- Target
- ZC3H11B
- Molecular classification
- Zinc finger protein (CCCH-type), Transcription factor, mRNA-binding protein, Other
01
Overview
Zinc finger CCCH-type containing 11B (ZC3H11B) is a protein-coding gene predicted to enable metal ion binding and is involved in the export of poly(A)+ mRNA from the nucleus, suggesting a role in post-transcriptional gene regulation[2][5]. ZC3H11B is structurally related to other zinc finger proteins, which serve as transcription factors or RNA-binding proteins influencing gene expression and numerous cellular processes[1][4]. Genetic studies have identified variants in ZC3H11B associated with ocular axial length and the risk and severity of myopia, indicating its relevance in eye growth and possibly in refractive error syndromes[2][5]. No evidence currently defines ZC3H11B as a direct therapeutic target or druggable protein, nor are there known small-molecule drugs or biologics targeting this gene[2][5]. Its most recognized implication is as a genetic biomarker for myopia susceptibility and progression[2][5].
- Other names
- ZC3H11BZC3HDC11Bzinc finger CCCH domain-containing protein 11BZinc finger CCCH-type domain containing 11B
02
Biological functions
mRNA bindingPoly(A)+ mRNA export from nucleusPotential transcription regulationOther
03
Disease associations
Degenerative myopiaDeafness and myopiaOther (linked to ocular axial length and refractive error)
04
Biomarkers
Genetic variants (SNPs) in ZC3H11B are candidate biomarkers for myopia risk and progression[2].
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