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Zinc finger CCCH-type containing 7A (ZC3H7A)
- Target
- ZC3H7A
- Molecular classification
- RNA-binding protein, CCCH zinc finger protein, Other (not a receptor, enzyme, transporter, or classic transcription factor)
01
Overview
Zinc finger CCCH-type containing 7A (ZC3H7A) is a member of the CCCH-type zinc finger protein family characterized by the presence of a zinc finger motif, which typically binds RNA rather than DNA. ZC3H7A **enables miRNA binding activity** and is involved in **miRNA processing**, regulating **post-transcriptional gene expression**[2][5][7][8]. It binds to the hairpin structures of specific microRNAs (MIR7-1, MIR16-2, MIR29A) via recognition of the 3'-ATA(A/T)-5' motif in their apical loop[7]. ZC3H7A is predicted to be located in the nucleus and may act as a specific regulator of miRNA biogenesis, influencing various cellular processes mediated by miRNAs[2][5][8]. While it is associated with some cancer types in genetic studies, it is not a classic therapeutic target such as a receptor or enzyme. The precise pathological mechanisms and clinical applications as a drug target or biomarker are not established.
- Other names
- Zinc finger CCCH domain-containing protein 7AZC3H7AZC3H7ZC3HDC7HSPC055FLJ20318zinc-finger protein AY163807
02
Biological functions
Post-transcriptional regulation of gene expressionmiRNA processingmiRNA binding activity
03
Disease associations
Cancer (associated with endometrial stromal tumor and endometrial stromal nodule; specific roles unknown)Other (no direct disease mechanism described, but possible role in gene regulation associated with disease)
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