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Target intelligence / Profile preview
Zinc finger CCCH type-containing protein 12C (ZC3H12C)
- Target
- ZC3H12C
- Molecular classification
- Enzyme, RNA-binding protein, Ribonuclease, Zinc finger protein
01
Overview
Zinc finger CCCH type-containing protein 12C (ZC3H12C) is a member of the CCCH-type zinc finger protein family, functioning as an RNA-binding protein with probable ribonuclease (RNase) activity. It participates in post-transcriptional regulation of gene expression by degrading specific mRNA targets, thereby modulating cellular processes such as macrophage activation and the innate immune response. ZC3H12C negatively regulates proinflammatory activation in macrophages, likely contributing to the control of inflammation during the immune response. Its activity is important for immune homeostasis, with emerging evidence implicating it in inflammation-related disease pathways.
- Other names
- Probable ribonuclease ZC3H12CKIAA1726MCPIP3MCP-induced protein 3Zinc finger CCCH domain-containing protein 12C
02
Mechanism of action
RNA endonuclease activity (degradation of specific mRNAs); Modulation of inflammatory gene expression
03
Biological functions
RNA metabolismRNA degradationRegulation of gene expressionNegative regulation of macrophage activationRegulation of inflammatory response
04
Disease associations
InflammationImmune response regulation
05
Safety considerations
Potential for deregulation of immune response or inflammation if targeted therapeutically
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