Zinc finger CCHC domain-containing protein 10 (ZCCHC10)

Zinc finger CCHC domain-containing protein 10 (ZCCHC10) is a member of the CCHC-type zinc finger protein superfamily characterized by the presence of a zinc-knuckle motif that confers high-affinity binding to single-stranded nucleic acids and supports protein-protein interactions, notably with tumor suppressor p53[1][2][5]. ZCCHC10 stabilizes and activates p53 by preventing its ubiquitin-mediated degradation, inducing cell cycle arrest at G1 phase and promoting apoptosis, particularly in cancer cells[2][4]. It is epigenetically silenced in some cancers by lncRNA SNHG1 and can be reactivated by hypomethylating agents or SNHG1 knockdown, which enhances sensitivity to drugs like venetoclax in AML[4]. ZCCHC10 has emerged as a promising tumor suppressor and therapeutic target in hematological and solid cancers due to its critical role in controlling cell proliferation and cell death through the p53 pathway[2][4].

Other names

ZCCHC10FLJ20094zinc finger, CCHC domain containing 10zinc finger CCHC-type containing 10zinc finger CCHC domain-containing protein 10

Indirect activation of p53 tumor suppressor pathway (by stabilizing p53 and preventing its degradation via interfering with MDM2 interaction). Enhancement of apoptosis (through p53 pathway, reduction of BCL2 expression). Synergistic cytotoxicity when combined with venetoclax (in AML models). Reactivation by hypomethylating agents and lncRNA SNHG1 knockdown (restores tumor suppressor function).