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Target intelligence / Profile preview
Zinc finger CCHC domain-containing protein 12 (ZCCHC12)
- Target
- ZCCHC12
- Molecular classification
- Transcriptional coactivator, Zinc finger protein, RNA-binding protein (putative), Other
01
Overview
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) is a transcriptional coactivator characterized by a CCHC-type zinc finger domain, primarily localizing to the nucleus.[4][6] Its principal function is to enhance bone morphogenetic protein (BMP) signaling by interacting with SMAD1 and CBP within transcriptional complexes, thereby influencing the expression of BMP-responsive genes, particularly in cholinergic neurons.[5][4][2] The protein is implicated in neurodevelopment, with genetic variations linked to X-linked intellectual disability and potentially other neurodevelopmental disorders.[4] ZCCHC12 is also identified as a metastasis-related oncogene in papillary thyroid cancer[1] and has been proposed as a marker for Cajal–Retzius cells and endometrial receptivity.[2] It does not function as a classic therapeutic target, receptor, or enzyme, and there are no approved drugs that directly act on ZCCHC12.
- Other names
- SIZN1SIZNFLJ16123PNMA7ASmad-interacting zinc finger protein 1paraneoplastic Ma antigen family member 7A
02
Biological functions
Transcriptional coactivationModulation of bone morphogenetic protein (BMP) signalingRegulation of gene expression in cholinergic neuronsSignal transduction (via Smad pathway)
03
Disease associations
Neurodevelopmental disorder (e.g., X-linked intellectual disability)Cancer (papillary thyroid cancer oncogene, possible involvement in other cancers)Other (potential marker in endometrial receptivity, mental retardation, and Cajal–Retzius cell biology)
04
Biomarkers
Potential biomarker in mental retardationpapillary thyroid cancer (research context only, not established clinical marker)
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