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Zinc finger CCHC-type containing 7 (ZCCHC7)
- Target
- ZCCHC7
- Molecular classification
- Transcription factor, RNA-binding protein, Zinc finger protein
01
Overview
Zinc finger CCHC-type containing 7 (ZCCHC7) is a protein-coding gene member of the ZCCHC superfamily, characterized by at least one CCHC-type zinc finger domain that mediates high-affinity nucleic acid binding, especially to single-stranded RNAs. ZCCHC7 functions primarily in nuclear RNA surveillance and degradation via its interaction with the nuclear exosome and PAPD5 as part of a mammalian TRAMP-like complex. These molecular activities participate in the accurate 3'-end formation and polyadenylation of RNAs including rRNAs, snRNAs, and snoRNAs, and elimination of excised RNA by-products, thereby maintaining RNA quality control and processing in the nucleolus. Disease association has been noted particularly in acute leukemias, but direct targeting by drugs or biomarker/clinical safety evidence is not currently available.
- Other names
- ZCCHC7Zinc finger protein CCHC-type 7Zinc finger CCHC-type containing protein 7ZCCHC-7
02
Biological functions
Nuclear RNA surveillanceRNA bindingRNA degradation (nuclear exosome function)3'-end formation of functional RNAsProtein-protein interaction (in the TRAMP-like complex)Nucleic acid binding
03
Disease associations
Leukemia (Acute lymphoblastic leukemia, Acute myeloid leukemia)Other possible roles in cancer due to broader family association
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