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Zinc finger CW-type and PWWP domain-containing protein 1 (ZCWPW1)
- Target
- ZCWPW1
- Molecular classification
- Histone modification reader (specifically dual methylation: H3K4me3, H3K36me3), Zinc finger domain protein (CW-type), PWWP domain-containing protein, Chromatin-associated protein (epigenetic regulator)
01
Overview
Zinc finger CW-type and PWWP domain-containing protein 1 (ZCWPW1) is a dual histone methylation reader protein specific for PRDM9-catalyzed marks (H3K4me3 and H3K36me3), playing essential roles in male fertility and spermatogenesis[1][2][7]. It facilitates the repair of meiotic double-strand breaks and is required for proper progression of meiosis prophase I in male germ cells[2][3][7]. The protein contains a CW-type zinc finger domain, which acts as a histone tail modification reader, and a PWWP domain associated with chromatin binding[1][2][7]. ZCWPW1 is encoded by the ZCWPW1 gene, expressed in testis and several tissues, and linked to disease roles such as ciliary dyskinesia, frontotemporal dementia/ALS, and male infertility[2][5][7]. There are currently no known drugs targeting ZCWPW1, and its modulation might present safety risks related to reproductive health.
- Other names
- ZCWPW1ZCPW1_HUMANQ9H0M4
02
Mechanism of action
Not applicable/none identified (no current drugs directly targeting ZCWPW1)
03
Biological functions
Reading histone methylation marks (specifically H3K4me3 and H3K36me3)Regulation of meiosis I (essential for homologous chromosome pairing and DNA repair during meiotic recombination, especially in male germ cells)Positive regulation of DNA metabolic processSpermatogenesis (promotes male fertility)
04
Disease associations
Associated with ciliary dyskinesia, primary, 6Associated with frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (FTD/ALS)Male infertility (due to its role in meiosis and spermatogenesis)Other roles possible in DNA repair-related disorders (based on DNA recombination function)
05
Safety considerations
No explicit therapeutic safety concerns reported.Perturbation may cause male infertility or meiosis defects (caution would be required for any future therapies targeting this protein)
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