Zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9)

Zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) is an integral membrane enzyme of the DHHC (Asp-His-His-Cys) protein family that mediates the palmitoylation of protein substrates, including key signaling proteins such as HRAS, NRAS, ADRB2, CGAS, and GSDMD[1][2][3][4]. ZDHHC9 forms complexes with accessory proteins (e.g., golgin subfamily A member 7) and modulates processes including membrane association, protein localization, innate immunity, and cell death. Mutations in the ZDHHC9 gene are causative for X-linked intellectual disability syndromes, and altered expression or activity has implications for cancer progression and viral infection. The enzyme is a therapeutic target in research due to its regulatory roles in cell signaling and immune response[1][2][3][4].

Other names

Zinc finger DHHC-type palmitoyltransferase 9ZDHHC9DHHC9Palmitoyltransferase ZDHHC9Zinc finger protein 379Zinc finger protein 380CGI-89ZDHHC10CXorf11MMSA1MRXSRMRXSZantigen MMSA-1UNQ261/PRO298golgin subfamily A member 7 complex protein

Drugs/compounds targeting this molecule would typically act as palmitoyltransferase inhibitors or block the enzyme's function, thereby preventing palmitoylation of substrates like HRAS, NRAS, GSDMD, CGAS, and possibly viral proteins. Specific inhibition may disrupt signal transduction, innate immunity, or tumor cell growth depending on substrate.