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Target intelligence / Profile preview
Zinc finger E-box-binding homeobox 2 mRNA (ZEB2 mRNA)
- Target
- ZEB2 mRNA
- Molecular classification
- Transcription factor (encoded protein), Messenger RNA
01
Overview
Zinc finger E-box-binding homeobox 2 (ZEB2) mRNA is the transcript encoding the ZEB2 protein, a member of the ZEB family of transcription factors (UniProt: O60315). It is a master regulator of the epithelial-mesenchymal transition (EMT), a process where epithelial cells lose polarity and gain migratory properties (PubMed: 28611535). ZEB2 is essential for neural crest development and organogenesis, and its haploinsufficiency leads to Mowat-Wilson syndrome, characterized by intellectual disability and distinct facial features (NIH: GeneReviews). In oncology, ZEB2 mRNA is often upregulated, driving metastasis and drug resistance in cancers such as breast, lung, and colorectal carcinoma (PubMed: 30217957). Therapeutic targeting of ZEB2 mRNA using antisense oligonucleotides (ASOs) or siRNAs aims to restore E-cadherin expression and inhibit tumor spread (PubMed: 25605103). Additionally, the miR-200 family of microRNAs acts as a natural antagonist to ZEB2 mRNA, and miR-200 mimics are being investigated as potential therapeutics (PubMed: 18485877).
- Other names
- SIP1SMADIP1ZFHX1BZinc finger homeobox 1bZEB2 transcript
02
Mechanism of action
RNA interference (RNAi), Antisense-mediated mRNA degradation, Translational repression
03
Biological functions
Epithelial-mesenchymal transitionNeural developmentTranscriptional regulationCell migrationOrganogenesis
04
Disease associations
CancerMowat-Wilson syndromeFibrosisMetastasis
05
Safety considerations
Off-target effectsDelivery vehicle toxicityDevelopmental toxicityDisruption of normal tissue homeostasis
06
Interacting drugs
Antisense oligonucleotides (experimental)
2 more in the full profile.
07
Biomarkers
ZEB2 mRNA expression levelsE-cadherin (CDH1) protein levelsVimentin protein levels
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