Zinc finger FYVE-type containing 27 (ZFYVE27)

Zinc finger FYVE-type containing 27 (ZFYVE27, also known as Protrudin) is a peripheral membrane protein and a member of the FYVE protein family that binds phosphatidylinositol 3-phosphate and associates with the endosomal/endoplasmic reticulum membrane. ZFYVE27 contains several functional domains, including a Rab11-binding domain at the N-terminal region, a coiled-coil domain, and a FYVE finger domain at the C-terminal end, enabling it to interact with multiple partners involved in membrane trafficking and endoplasmic reticulum morphogenesis. The protein promotes neurite extension and axonal elongation in neurons by mediating vesicular transport and establishing neuronal polarity. Mutations in ZFYVE27 are associated with hereditary spastic paraplegia, highlighting its importance in neurodegenerative disease and suggesting potential as a therapeutic target. Oligomerization (dimer/tetramer forms) of ZFYVE27 is required for its function in neurite outgrowth, and functional disruption can cause pathological changes in neuronal morphology, including cytoplasmic swelling and altered ER structure.

Other names

ProtrudinSPG33Spastic paraplegia 33 proteinFLJ32919Zinc finger FYVE domain-containing protein 27SPG33 proteinZinc finger FYVE-type containing 27ZFYVE27

Not applicable, as no interacting drugs are listed in current sources.