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Target intelligence / Profile preview
Zinc finger FYVE-type containing 28 (ZFYVE28)
- Target
- ZFYVE28
- Molecular classification
- Zinc finger protein, Receptor regulatory protein, FYVE domain-containing protein, Other (Endosomal signaling regulator)
01
Overview
Zinc finger FYVE-type containing 28 is a human protein encoded by the ZFYVE28 gene, localized primarily in the cytosol and early endosome membrane[1][2][3][4][5]. It contains a FYVE domain which mediates phosphatidylinositol-3-phosphate binding. ZFYVE28 acts as a negative regulator of epidermal growth factor receptor (EGFR) signaling by promoting EGFR degradation in endosomes, particularly when the protein is not monoubiquitinated[1][5]. Additionally, ZFYVE28 has been reported to mediate insulin resistance by promoting the degradation of the phosphorylated insulin receptor via increased late endosome production[4]. Disease associations include certain rare autoimmune and infectious conditions, and it is involved in cellular pathways associated with cancer and metabolic disease[1][4].
- Other names
- ZFYVE28LST2LYST2lst-2zinc finger FYVE-type containing 28
02
Mechanism of action
Drugs targeting this molecule would likely act by modulating receptor degradation and signaling downregulation, especially of EGFR and insulin receptor
03
Biological functions
Negative regulation of epidermal growth factor receptor (EGFR) signalingPromotes EGFR degradation in endosomesPhosphatidylinositol-3-phosphate bindingPromotes degradation of phosphorylated insulin receptor via increased late endosome production
04
Disease associations
Cancer (by modulation of EGFR signaling)AdiaspiromycosisAnti-basement membrane glomerulonephritisInsulin resistance
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