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Target intelligence / Profile preview
Zinc finger homeobox protein 2 (ZFHX2)
- Target
- ZFHX2
- Molecular classification
- Transcription factor, Homeobox protein, Zinc finger protein
01
Overview
Zinc finger homeobox protein 2 (ZFHX2) is a DNA-binding transcription factor characterized by multiple zinc finger and homeobox domains, crucial for the regulation of sensory perception of pain and processing of noxious stimuli. It is located in the nucleus and predominantly influences neuronal gene expression. Mutations in ZFHX2 are implicated in Marsili syndrome, a rare hereditary pain insensitivity disorder, and are associated with hereditary sensory neuropathy. There are no known small molecule or therapeutic agents that directly target this transcription factor[1][2][3][4][7].
- Other names
- ZFHX2KIAA1056KIAA1762ZNF409ZFH-2ZFH-5MARSISZFH5zinc finger homeobox protein 2zinc finger protein 409zinc finger homeodomain protein 2
02
Biological functions
Regulation of sensory perception of painRegulation of neuron differentiationRegulation of transcription by RNA polymerase IIDNA-binding transcription factor activityProcessing of noxious stimuli
03
Disease associations
Marsili syndromeHereditary sensory neuropathy
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