Zinc finger homeobox protein 3 (ZFHX3)

Zinc finger homeobox protein 3 (ZFHX3) is a large transcription factor characterized by multiple zinc finger motifs and homeodomains. It regulates gene expression by binding to AT-rich motifs in enhancers and promoters, orchestrating diverse biological processes such as neuronal and myogenic differentiation, cell cycle regulation, and suppression of oncogenes. ZFHX3 has key physiological roles in tumor suppression, circadian rhythm regulation (notably in the suprachiasmatic nucleus), and cardiovascular function. Loss or mutation of ZFHX3 is associated with several cancers, cardiovascular diseases (especially atrial fibrillation), neurodevelopmental disorders, and inflammation. ZFHX3 can serve as a biomarker for certain cancer immunotherapies and for prognosis in atrial fibrillation and other disease states[1][2][3][4].

Other names

Zinc finger homeobox 3ZFHX3ATBF1C16orf47ZFH-3ZNF927FLJ26184AT motif-binding factor 1AT-binding transcription factor 1Alpha-fetoprotein enhancer-binding proteinZinc finger homeodomain protein 3ATBTATFB8SCA4

Transcriptional regulation by DNA binding at AT-rich enhancers and promoters[2][1]\nModulation of gene expression related to cell cycle, apoptosis, and differentiation[2]\nSuppression or activation of specific growth-control genes (e.g., alpha-fetoprotein, c-Myb, CDKN1A)[2]