Zinc finger imprinted 2 (ZIM2)

Zinc finger imprinted 2 (ZIM2) is a protein-coding gene belonging to the zinc finger protein family. In humans, ZIM2 and the adjacent PEG3 gene share a set of 5' exons and a common promoter, resulting in coordinated paternal expression. ZIM2 is predicted to function as a DNA-binding transcription factor and may regulate gene expression through nucleic acid interaction[1][3][7]. ZIM2 is expressed in various tissues with highest levels observed in adult testis, and modest levels in fetal kidney[4]. In terms of evolution, ZIM2 maintains a conserved genomic position near PEG3 across mammals, but its imprinting status and transcriptional regulation differ between species[1][2][6]. There is limited evidence suggesting ZIM2 is a direct therapeutic target; its association with diseases like Beckwith-Wiedemann syndrome and neonatal diabetes is likely as a candidate gene implicated by genetic studies, not as a pharmacological target[3]. No drugs, mechanisms of action, or biomarker roles are currently established for ZIM2 in the therapeutic context.

Other names

ZIM2Zinc finger protein 656ZNF656zinc finger imprinted 2zinc finger protein 656