Zinc finger MYM-type protein 3 (ZMYM3)

Zinc finger MYM-type protein 3 (ZMYM3) is a highly conserved protein encoded on the X chromosome, subject to X inactivation, and most abundantly expressed in the brain. It serves as a scaffold protein bridging transcriptional regulation with chromatin modification and RNA processing. ZMYM3 is a critical component of histone deacetylase-containing multiprotein complexes (such as the CoREST complex) that help maintain gene silencing via chromatin structure remodeling. Notably, ZMYM3 harbors an exceptionally long GA short tandem repeat (STR) in its 5′ untranslated region; variation in the length of this STR has been linked to schizophrenia, bipolar disorder, late-onset neurocognitive disorders, and intellectual disability, implicating ZMYM3 in cognitive and neuropsychiatric disease risk. Rare coding variants have also been associated with developmental delay, intellectual disability, and behavioral abnormalities, suggesting hypomorphic effects and a crucial role in neural development. There are no drugs currently known to target ZMYM3 directly, and it is not considered a classical therapeutic target (such as a receptor or enzyme).

Other names

ZNF261ZNF198L2DXS6673EKIAA0385MYMXFIMXLID112

No targeted therapies documented; ZMYM3 is not currently recognized as a direct therapeutic target in the context of drug development