Zinc finger MYM-type protein 4 (ZMYM4)

Zinc finger MYM-type protein 4 (ZMYM4) is a nuclear transcription factor containing multiple MYM-type zinc finger domains (nine in the human protein) that enable DNA binding and interactions with other nuclear proteins[1][3][4]. ZMYM4 functions in the regulation of gene expression during embryonic development, particularly in craniofacial tissues, neural crest, neural plate, and branchial arches[1]. It does not function as a cofactor for Six1, despite structural similarities to Sine oculis binding protein. In the nucleus, ZMYM4 interacts physically and functionally with other transcription factors such as B-MYB and ZMYM2, and is subject to regulation via SUMOylation[3]. Mutations or dysregulation of ZMYM4 have been associated with several human diseases, including cancer, obesity, schizophrenia, substance use disorders, and sleep disorders, suggesting roles in tumorigenesis, neurodevelopment, and metabolism[1]. Its precise molecular mechanisms are still being elucidated, but it is implicated in DNA binding, cytoskeleton organization, and cell morphogenesis[1][4][5]. There are currently no drugs or established biomarkers directly targeting or involving ZMYM4, and it is not considered a canonical therapeutic target at this time.

Other names

KIAA0425ZNF262ZNF198L3CDIRcell death inhibiting RNAzinc finger protein 262zinc finger, MYM-type 4