Target intelligence / Profile preview

Zinc finger MYM-type protein 5 (ZMYM5)

Target: ZMYM5
Molecular classification: Transcription factor, Zinc finger protein, Chromatin-associated protein

Overview

Zinc finger MYM-type protein 5 (ZMYM5) is a nuclear transcriptional regulator containing MYM-type zinc finger domains, thought to function as a transcriptional repressor by binding to DNA and modulating gene expression through the negative regulation of transcription by RNA polymerase II. It is implicated in chromatin organization and may play a part in the tumorigenic process when fused with other genes but is not recognized as a primary therapeutic target or established disease biomarker[3][2][10][1][9][5].

Other names: MYMZNF198L1ZNF237HSPC050Zinc finger protein 198-like 1Zinc finger protein 237

Biological functions

Negative regulation of transcription by RNA polymerase IIZinc ion bindingTranscriptional repressionChromatin organization

Disease associations

Dyskeratosis congenita (autosomal recessive 2)Other (general transcriptional regulation implicated in cancer via gene fusions, but not a primary disease-associated gene)

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