Zinc finger MYND domain-containing protein 10 (ZMYND10)

Zinc finger MYND domain-containing protein 10 (ZMYND10) is a cytoplasmic protein that plays a critical role in the assembly and function of motile cilia. It acts as a co-chaperone in a protein complex that assists in the pre-assembly and stabilization of dynein arms—core molecular structures needed for the movement of cilia. Specifically, ZMYND10 interacts with other assembly factors (such as LRRC6, FKBP8, and HSP90) and is essential for axonemal (the ciliary “skeleton”) organization and motility[1][2][3][4][6]. Mutations in ZMYND10 disrupt dynein arm formation, leading to the inherited disorder **primary ciliary dyskinesia (PCD)**, characterized by defective ciliary movement and a spectrum of clinical symptoms including chronic respiratory tract infections and defects in left-right body asymmetry[2][3][5][6]. ZMYND10 is also recognized as a tumor suppressor gene, frequently altered in certain cancers[6]. There are currently no known drug interactions or therapies precisely targeting ZMYND10.

Other names

BLULUCA12.4CILD22DNAAF7Protein BLuDynein axonemal assembly factor 7Tumor suppressor BLUFLU