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Target intelligence / Profile preview
Zinc finger MYND domain-containing protein 12 (ZMYND12)
- Target
- ZMYND12
- Molecular classification
- Other (Axonemal complex protein), Zinc finger protein, MYND domain-containing protein
01
Overview
Zinc finger MYND domain-containing protein 12 (ZMYND12) is a previously uncharacterized protein containing a MYND-type zinc finger domain, expressed predominantly in the testis and playing a critical role in the structure and function of the sperm flagellum[1][4]. ZMYND12 localizes to the axoneme of the sperm flagellum, where it forms a complex with other axonemal proteins, such as TTC29 and DNAH1, and is essential for the proper assembly and stability of several flagellar components including the inner dynein arms and the calmodulin- and spoke-associated complex (CSC)[1][4]. Bi-allelic loss-of-function variants in ZMYND12 cause severe axonemal disorganization, leading to the MMAF phenotype and male infertility in humans; analogous phenotypes have been observed in model organisms[1][4]. ZMYND12's activity appears limited to ciliated/flagellated cell structures and no therapeutic targeting or biomarker roles are currently reported.
- Other names
- Zinc finger MYND-type containing 12DKFZp434N2435Zmynd12zmynd12MYND domain-containing zinc finger protein 12
02
Biological functions
Sperm flagellum structure and functionCiliary/flagellar motilityAxoneme assembly and stability
03
Disease associations
Male infertility (specifically Multiple Morphological Abnormalities of the Sperm Flagella, MMAF)Other
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