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Target intelligence / Profile preview
Zinc finger MYND domain-containing protein 19 (ZMYND19)
- Target
- ZMYND19
- Molecular classification
- Regulatory protein, Zinc finger protein, Adaptor
01
Overview
Zinc finger MYND domain-containing protein 19 (ZMYND19) is a protein coded by the ZMYND19 gene, highly conserved across species and characterized by a MYND-type zinc finger domain. It was originally discovered as a protein from human brain tissue that interacts with the C-terminus of melanin-concentrating hormone receptor 1 (MCH-R1; also known as GPR24), as well as the N-termini of alpha- and beta-tubulin. ZMYND19 may serve as a regulatory protein linking membrane receptor signaling (via MCH-R1) to microtubule-associated proteins, but its specific biological functions have yet to be fully clarified. The gene has been associated with Kleefstra syndrome 1, but no direct role in common therapeutic areas or with any known drugs has been reported.
- Other names
- ZMYND19Zinc finger MYND-type containing 19Zinc finger MYND domain-containing protein 19MIZIPMCH-R1-interacting zinc finger proteinMelanin-concentrating hormone receptor 1-interacting zinc finger proteinZinc finger, MYND domain containing 19
02
Mechanism of action
Null
03
Biological functions
Protein-protein interactionMay act as a regulatory molecule in GPR24/MCH-R1 signalingMay provide a link between MCH-R1 and tubulin functions in mammalian cells
04
Disease associations
Kleefstra syndrome 1Kleefstra syndrome
05
Safety considerations
Null
06
Interacting drugs
None known
07
Biomarkers
Null
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