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Zinc finger protein 135 (ZNF135)
- Target
- ZNF135
- Molecular classification
- Transcription factor, C2H2 zinc finger protein, Krüppel-associated box (KRAB) domain protein
01
Overview
Zinc finger protein 135 (ZNF135) is a C2H2-type zinc finger transcription factor featuring a Krüppel-associated box (KRAB) domain, encoded on chromosome 19q13.43[2]. It is predicted to function as a DNA-binding transcription factor, specifically regulating transcription mediated by RNA polymerase II and is thought to influence cell morphology and cytoskeletal organization, possibly via transcriptional regulation of key genes[4][5][6]. ZNF135 belongs to a large family of zinc finger proteins involved in a spectrum of biological processes including gene expression, development, and differentiation. While the broader zinc finger family is implicated in disease processes such as cancer, neurodegenerative diseases, and immune response disorders[1][3], there is currently no direct evidence indicating ZNF135's involvement as a therapeutic target or in drug interactions.
- Other names
- Zinc finger protein 135ZNF61ZNF78L1pHZ-17Zinc finger protein 61Zinc finger protein 78-like 1pT3
02
Biological functions
DNA bindingRegulation of transcription by RNA polymerase IIRegulation of cell morphology and cytoskeletal organization
03
Disease associations
Potential association with development and differentiationGeneral roles in cancer and neuro-related disorders by analogy to similar zinc finger proteins, but no direct evidence specific to ZNF135
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