Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Zinc finger protein 136 (ZNF136)
- Target
- ZNF136
- Molecular classification
- Transcription factor, Zinc finger protein, KRAB domain-containing protein
01
Overview
Zinc finger protein 136 is a transcription factor encoded by the ZNF136 gene in humans. It contains a KRAB A-box at its N-terminus with weak transcriptional repressor activity, followed by fourteen C2H2-type zinc finger domains and one degenerate zinc finger. Its molecular function is primarily in RNA polymerase II cis-regulatory sequence-specific DNA binding and zinc ion binding. ZNF136 may modulate host cell transcriptional responses, notably during viral infections such as hepatitis C. Multiple transcript variants exist due to alternative splicing. ZNF136 is mainly classified within the zinc finger and KRAB domain family of transcriptional regulators.
- Other names
- ZNF136pHZ-20PHZ-20zinc finger protein 136
02
Mechanism of action
null
03
Biological functions
Transcriptional repressionNegative regulation of gene expressionRNA polymerase II sequence-specific DNA binding
04
Disease associations
Other (implicated in host cell transcriptional response to Hepatitis C virus infection; no established role in major human diseases like cancer or inflammation)
Beyond the preview
Go deeper on Zinc finger protein 136 (ZNF136).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Zinc finger protein 136 (ZNF136).