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Zinc finger protein 138 (ZNF138)
- Target
- ZNF138
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 138 (ZNF138) is a member of the zinc finger transcription factor family, characterized by its ability to bind specific DNA sequences and regulate gene expression. It is predicted to modulate RNA polymerase II-dependent transcription, likely through sequence-specific interactions with cis-regulatory DNA elements. ZNF138 is localized to the membrane and nucleus, consistent with transcription factor activity. It contains conserved zinc finger domains responsible for DNA and metal ion binding. While ZNF138 has been linked to functional genomics associations, there is currently no evidence supporting its role as a major therapeutic target, nor are there drugs directly interacting with it[1][2][3][4][6].
- Other names
- ZNF138PHZ-32pHZ-32zinc finger protein 138 (clone pHZ-32)
02
Biological functions
Regulation of DNA-templated transcriptionDNA-binding transcription factor activity (RNA polymerase II-specific)Sequence-specific DNA bindingMetal ion binding
03
Disease associations
Cancer (some association via text-mining and functional genomics datasets, but not a major validated disease gene)
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