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Zinc finger protein 140 (ZNF140)
- Target
- ZNF140
- Molecular classification
- Transcription factor, C2H2-type zinc finger protein
01
Overview
Zinc finger protein 140 (ZNF140) is a human protein belonging to the C2H2-type zinc finger protein family and functions as a transcription factor, primarily acting as a repressor that binds specific DNA sequences to negatively regulate gene expression by RNA polymerase II. It contains multiple zinc finger domains, which enable high-affinity binding to double-stranded DNA, allowing the protein to modulate gene expression in the nucleus.
- Other names
- ZNF140pHZ-39zinc finger protein 140
02
Biological functions
Transcriptional repressionDNA bindingNegative regulation of transcription by RNA polymerase II
03
Disease associations
Other (associated with stereotypic movement disorder, but not a well-characterized role in major disease categories like cancer, inflammation, etc.)
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