Zinc finger protein 154 (ZNF154)

Zinc finger protein 154 (ZNF154) is a DNA-binding transcription factor of the Kruppel family, implicated in transcriptional regulation via zinc finger domains[2][8]. It acts as a tumor suppressor in epithelial-derived cancers, with promoter hypermethylation leading to its silencing and tumor progression[1]. ZNF154 directly regulates genes involved in proliferation, migration, and tumor suppression, notably through pathways such as cell cycle control and p53/Wnt signaling[1]. Reactivation of ZNF154 by epigenetic editing (e.g., CRISPR/dCas9-Tet1 or 5-aza-dC) restores its tumor suppressive functions, highlights its value as both a biomarker and therapeutic target in cancer[1][2][8].

Other names

ZNF154KIAA2003pHZ-92zinc finger protein 154

Epigenetic modulation (e.g., demethylation of promoter regions restores ZNF154 expression and inhibits tumor cell proliferation/migration; drugs like 5-aza-dC promote re-expression)