Zinc finger protein 169 (ZNF169)

Zinc finger protein 169 (ZNF169) is a DNA-binding transcription factor belonging to the C2H2-type zinc finger protein family, and is encoded by the ZNF169 gene located on chromosome 9q22.3[1][4]. ZNF169 functions by binding RNA polymerase II transcription regulatory regions and directly interacts with the promoter of the ANKZF1 gene, upregulating its transcription[2][3]. Overexpression of ZNF169 promotes cell proliferation and suppresses apoptosis in colorectal cancer models, suggesting an oncogenic role—especially via the ZNF169/ANKZF1 axis[2][3]. The expression and function of ZNF169 in other tissues and cancers is still being investigated, but bioinformatic and cell-based studies implicate it in cancer progression and possibly other transcriptional regulatory pathways.

Other names

MGC51961

No drugs are specifically known to target ZNF169 directly. Theoretically, drugs that inhibit the ZNF169/ANKZF1 axis could act by suppressing ZNF169-mediated transcriptional activation, thereby reducing cell proliferation and improving apoptosis in cancer (inferred from disease mechanism studies)