Zinc finger protein 175 (ZNF175)

Zinc finger protein 175 (ZNF175, also known as OTK18) is a transcription factor containing 13 contiguous C2H2-type zinc finger motifs, encoded by the ZNF175 gene on human chromosome 19[5]. It is primarily located in the cytosol and nucleolus[2]. ZNF175 functions as a transcriptional regulator—repressing and activating RNA polymerase II-mediated transcription of specific gene sets. It down-regulates chemokine receptor expression and can inhibit HIV-1 replication by suppressing Tat-dependent transcription of the viral LTR promoter, suggesting a functional role in innate immune regulation[2][6]. Diseases associated with ZNF175 include various forms of non-syndromic X-linked intellectual disability, and its upregulation in macrophages upon HIV infection has been described, indicating significance in infection biology and immune responses[1][2].

Other names

ZNF175OTK18zinc finger protein OTK18zinc finger protein 175

Not established; current mechanistic insights relate to transcriptional suppression of viral genes and chemokine receptor regulation rather than established drug mechanisms