Target intelligence / Profile preview

Zinc finger protein 180 (ZNF180)

Target
ZNF180
Molecular classification
Transcription factor, Zinc finger protein family
01

Overview

Zinc finger protein 180 (ZNF180) is a member of the zinc finger protein family with a conserved motif that coordinates zinc ions via cysteine and histidine residues. These domains enable it to bind nucleic acids and regulate transcription, suggesting a role as a DNA-binding transcription factor. Although zinc finger proteins are implicated widely in cellular processes—such as transcriptional regulation, signal transduction, and disease mechanisms—direct evidence linking ZNF180 to any specific biological process, disease mechanism, or drug interaction is currently limited. ZNF180 is primarily noted in gene ontology annotations for nucleic acid binding and transcription regulation; however, its distinct clinical, therapeutic, or biomarker status remains undefined, and it is not an established therapeutic target.

Other names
ZNF180HHZ168zinc finger protein 180
02

Biological functions

DNA bindingTranscriptional regulationNucleic acid bindingProtein bindingPossible interaction with metal ions (zinc coordination)
03

Disease associations

Fanconi anemia, complementation group G (reported association)Generic zinc finger proteins roles in cancer, neurodegeneration, and diabetes are documented, but not specifically for ZNF180

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