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Zinc finger protein 184 (ZNF184)
- Target
- ZNF184
- Molecular classification
- Transcription factor, Zinc finger protein (C2H2 type)
01
Overview
Zinc finger protein 184 is a KRAB-domain, C2H2-type zinc finger transcription factor robustly expressed in the human brain and other tissues. It binds DNA via zinc finger motifs and represses transcription of target genes. ZNF184 is implicated in cancer susceptibility and neurological disorders such as Parkinson’s disease, where reduced ZNF184 levels correlate with disease state. Its regulatory function involves direct binding to promoter regions (e.g., ILF3), modulating gene networks relevant to cell survival, metabolic processes, and oncogenic signaling. While not currently a direct target of approved drugs, its pathway components (such as miR-7 in PD) may be pharmacologically modulated.
- Other names
- ZNF184kr-ZNF3zinc finger protein 184zinc finger protein 184 (Kruppel-like)
02
Mechanism of action
Transcriptional repression of target genes (e.g., by binding to the ILF3 promoter and suppressing its expression) Indirect modulation of non-coding RNA and protein-coding gene networks
03
Biological functions
DNA bindingTranscriptional regulation/repressionRegulation of gene expression
04
Disease associations
Cancer (lung cancer, prostate cancer, esophageal squamous cell carcinoma)Neurodegenerative disease (Parkinson's disease)Metabolic regulation (association with blood triglyceride levels)
05
Safety considerations
None specifically documented as major safety concerns for targeting ZNF184 directly; however, as a transcription factor regulating multiple genes, off-target effects or pleiotropic consequences could arise if therapeutically modulated
06
Interacting drugs
Scutellarin
07
Biomarkers
Decreased ZNF184 levels in substantia nigra and cortex in Parkinson's diseasePolymorphism rs6904596 associated with increased risk for lung cancer and altered triglyceride levels
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