Target intelligence / Profile preview

Zinc finger protein 19 (ZNF19)

Target
ZNF19
Molecular classification
Transcription factor, Zinc finger protein (C2H2 subtype is typical for such proteins[1][2][3][4])
01

Overview

Zinc finger protein 19 (ZNF19, KOX12) is a member of the large zinc finger protein family, characterized by its classical C2H2 domain, which stabilizes its structure and allows for flexible binding to various substrates—including DNA and RNA. Zinc finger proteins are among the most abundant transcription factor families, participating in transcription regulation, chromatin remodeling, and nucleic acid interactions. ZNF19 likely functions as a transcription factor, regulating gene expression through DNA binding, but its specific biological roles and implications in human disease are not fully elucidated[4][1][2][3]. No existing evidence designates ZNF19 as a drug target or clinical biomarker, nor are there associated safety concerns in therapeutic contexts. The broader zinc finger protein family does include members involved in disease pathology, including cancer and neurodegeneration, though direct links for ZNF19 have not been reported in current literature[2][3][4].

Other names
ZNF19KOX12MGC51021zinc finger protein KOX12zinc finger protein 19 (KOX 12)
02

Biological functions

Transcription regulation (gene activation and repression)Chromatin remodelingDNA bindingRNA/protein/lipid interactions (common to zinc finger proteins[1][2][3])
03

Disease associations

Cancer (some zinc finger proteins are implicated in oncogenesis and tumor suppression; specific involvement of ZNF19 remains unclear and is not directly documented[2][3][4].)Neurodegenerative disease, skin diseases, diabetes (family-level roles; no direct evidence for ZNF19 to date[3])

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