Zinc finger protein 195 (ZNF195)

Zinc finger protein 195 (ZNF195) is a member of the Krueppel C2H2-type zinc-finger protein family, which functions as a transcription factor involved in the regulation of gene expression through nucleic acid binding[1][3]. The gene is located on chromosome 11p15.5, adjacent to an imprinted domain associated with the development of Wilms’ tumors[1]. ZNF195 is expressed in various tissues, including adult heart, brain, placenta, skeletal muscle, pancreas, and in fetal lung, kidney, and brain[10]. Multiple alternative splicing variants exist[1]. Its precise biological targets and comprehensive disease involvement remain incompletely characterized. ZNF195 is not a classic therapeutic target (e.g., not a receptor, enzyme, or transport protein), and there are currently no drugs known to interact directly with ZNF195[1][10]. There is no evidence of notable direct safety or therapeutic concerns related to ZNF195 manipulation or targeting. The principal biological function is likely transcriptional regulation, inferred from its structure and family. Amme complex is the only directly associated disease, and clinical roles beyond putative biomarker associations are limited[1][9].

Other names

ZNFP104HRF1hypoxia-regulated factor-1krueppel family zinc finger protein (znfp104)