Zinc finger protein 200 (ZNF200)

Zinc finger protein 200 (ZNF200) is a human protein encoded by the ZNF200 gene. It belongs to the C2H2-type zinc finger family and contains a Krüppel-associated box (KRAB) domain, a feature common to many transcription factors involved in gene regulation[4][6][10]. ZNF200 is predicted to bind nucleic acids and locate to the nucleus[1][2][7][12]. Functional studies show it interacts with key nuclear regulators: it binds directly to G9a (EHMT2), a histone H3 lysine 9 methyltransferase, and with PRMT3, a protein arginine methyltransferase; these interactions suggest it may modulate epigenetic regulation by affecting histone methylation[2][3][11]. The biological role of ZNF200 is incompletely characterized. It may participate in gene expression control, protein localization, and nuclear processes, and there is suggestive evidence for a role in spermatogenesis[1]. ZNF200 has been associated with rare genetic diseases, but it is not a validated or actionable therapeutic target at present[1][4][12]. Its role in human health and disease is primarily inferred from its molecular interactions and gene family, rather than direct evidence from pharmacological or clinical studies.

Other names

ZNF200Zinc finger protein 200ZNFMFZN200_HUMAN

Not applicable—no drugs directly target ZNF200.