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Zinc finger protein 202 (ZNF202)
- Target
- ZNF202
- Molecular classification
- Transcription factor, Zinc finger protein, SCAN domain-containing protein, KRAB domain-containing protein
01
Overview
Zinc finger protein 202 (ZNF202) is a protein-coding transcription factor encoded by the human *ZNF202* gene, characterized by C2H2-type zinc finger DNA-binding motifs, a KRAB domain, and a SCAN domain[2][3]. It acts mainly as a transcriptional repressor, binding preferentially to the promoters of genes that play roles in lipid metabolism and energy homeostasis, including apolipoproteins, lipid-processing enzymes, and cholesterol/lipid transporters (e.g., ABCA1, ABCG1)[1][3]. ZNF202 was first described in the context of breast cancer[4] but is now strongly linked to cardiovascular and metabolic disorders, especially atherosclerosis and metabolic syndrome[3][4][6]. Dysfunction or genetic variation of ZNF202 can influence susceptibility to lipid disorders and related diseases. ZNF202 forms part of a broader network of transcriptional regulation through interactions mediated by its SCAN domain and is considered a potential therapeutic target in disorders of lipid metabolism and vascular disease[1].
- Other names
- ZNF202ZKSCAN10ZSCAN42Zinc finger protein with KRAB and SCAN domains 10
02
Biological functions
Negative regulation of transcription by RNA polymerase IITranscriptional repression of genes involved in lipid metabolismRegulation of energy homeostasisModulation of vascular and metabolic gene expression
03
Disease associations
Cardiovascular disease (e.g., atherosclerosis)Metabolic syndromeAbdominal obesityVascular diseaseCancer (notably breast cancer)
04
Safety considerations
Potential for broad effects on gene expression given its role as a transcriptional repressor
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