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Zinc finger protein 205 (ZNF205)

Target: ZNF205
Molecular classification: Transcription factor, Zinc finger protein

Overview

Zinc finger protein 205 (ZNF205) is a human transcription factor belonging to the zinc finger protein family, predicted to enable sequence-specific DNA binding and regulation of RNA polymerase II-mediated gene transcription[1][3][7]. It acts mainly as a transcriptional repressor, influencing the expression of genes such as MPV17L, thus modulating cellular processes including hydrogen peroxide metabolism, mitochondrial outer membrane permeabilization, and the intrinsic apoptotic pathway[1][3][7]. ZNF205 is linked to cancer and developmental disorders, but there are no known drug interactions or therapeutic targeting strategies as of current data[1][3][4][7].

Other names: Transcriptional repressor RHITZNF210RhitHZfp13Repressor of heat-inducible transcriptionZinc finger protein 210RHITtranscriptional repressor RhitHzinc finger protein 210ZNF205

Biological functions

Negative regulation of transcription by RNA polymerase IIPositive regulation of hydrogen peroxide biosynthetic processPositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signalingDNA-binding transcription factor activity (RNA polymerase II-specific)Sequence-specific DNA bindingRegulation of MPV17L expression and downstream apoptotic and H₂O₂ metabolism pathways

Disease associations

Cancer (specifically Adult Acute Monocytic Leukemia)Developmental disorders (Holoprosencephaly 12 with or without pancreatic agenesis)Other (due to general roles in apoptosis and mitochondrial regulation)

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