Zinc finger protein 207 (ZNF207)

Zinc finger protein 207 (ZNF207), also known as BuGZ or BUGZ, is a kinetochore- and microtubule-associated protein that plays an essential role in spindle assembly and chromosome alignment during mitosis and meiosis. It binds microtubules, facilitates the assembly of the mitotic spindle and spindle matrix, and regulates the stability and kinetochore loading of the spindle assembly checkpoint protein BUB3, partly via its GLEBS motif. ZNF207's actions are crucial for correct kinetochore-microtubule attachments, chromosome alignment, and mitotic checkpoint activity. Loss of ZNF207 disrupts spindle formation, leads to chromosome misalignment, and results in a high incidence of errors in chromosome segregation, such as aneuploidy, especially in oocyte meiosis. Dysregulation or mutation of ZNF207 may contribute to diseases involving mitotic errors, such as cancer and reproductive tract diseases, although it is not currently a direct therapeutic target[1][2].

Other names

BUGZBuGZhBuGZBUB3-interacting and GLEBS motif-containing protein ZNF207Zfp207

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