Zinc finger protein 208 (ZNF208)

Zinc finger protein 208 is a member of the Kruppel-type zinc finger transcription factors containing C2H2 motifs, encoded by the ZNF208 gene on chromosome 19. It binds specific DNA sequences to regulate gene transcription, influencing various cell processes, especially transcriptional control mechanisms essential for cellular function and development. Several genetic variants in ZNF208 are associated with increased risk for certain cancers (including esophageal and laryngeal cancers), vascular diseases (such as ischemic stroke and coronary heart disease), and may relate to telomere length, with implications for aging and chronic disease. Despite these associations, ZNF208 itself is not considered a druggable or direct therapeutic target at present.

Other names

ZNF208ZNF95PMIDPzinc finger protein 208zinc finger protein 95zinc finger protein 91-like

Not established for pharmacologic targeting; ZNF208 functions principally as a transcription factor that recognizes specific DNA sequences and regulates gene expression