Zinc finger protein 212 (ZNF212)

Zinc finger protein 212 (ZNF212) is a member of the C2H2-type zinc finger protein family, which primarily functions as a transcription factor and is involved in the regulation of gene expression[10][3][9]. ZNF212 contains three functional domains: a DUF3669 domain (function unknown), a KRAB domain (typically involved in transcriptional repression), and classical C2H2 zinc finger domains (bind DNA)[1]. ZNF212 has been shown to promote genomic integrity by acting directly in DNA repair pathways—specifically, by interacting with TRAIP and NEIL3, participating in the DNA damage response, homologous recombination, and interstrand crosslink repair[2][8]. Loss of ZNF212 results in Purkinje cell death, suggesting a critical role in neural cell survival[1]. ZNF212 may function upstream of certain repair pathways, including NEIL3 and Fanconi anemia pathways[8]. There are currently no direct reports of pharmacological modulators or drugs targeting ZNF212, nor established uses as a biomarker or therapeutic target in disease.

Other names

ZNF212ZNFC150C2H2-150Zinc finger protein C2H2-150ZNF182