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Zinc finger protein 235 (ZNF235)

Target: ZNF235
Molecular classification: Transcription factor, Zinc finger protein (C2H2-type), Kruppel-associated box (KRAB) family

Overview

Zinc finger protein 235 (ZNF235) is a member of the Kruppel family of zinc finger proteins within the zinc finger protein superfamily[1]. It contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc finger domains, making it a prototypical C2H2-type DNA-binding transcription factor[1][3]. ZNF235 is thought to function in the transcriptional regulation of gene expression, though precise downstream genes and cellular roles remain incompletely characterized[1]. It is an ortholog of the mouse Zfp93 protein and is located in a cluster of zinc finger genes on human chromosome 19q13.2[1]. Diseases associated directly with ZNF235 include esophageal adenosquamous carcinoma and alexithymia[1]. There are no known therapeutic drugs targeting ZNF235 as of current available data.

Other names: Zinc finger protein 235ZNF235ZFP93ZNF270Zfp-93HZF6ANF270Zinc finger protein 270Zinc finger protein 93 homologZinc finger protein HZF6zinc finger protein homologous to Zfp93 in mouse

Biological functions

Transcriptional regulationNucleic acid binding

Disease associations

Cancer (specifically associated with esophageal adenosquamous carcinoma)AlexithymiaOther (for zinc finger family generally, including a wide variety of cancers and some neurodegenerative associations—but no direct evidence for ZNF235 beyond esophageal cancer and alexithymia[1][3][4])

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