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Zinc finger protein 253 (ZNF253)
- Target
- ZNF253
- Molecular classification
- Transcription factor, DNA-binding protein, Zinc finger protein
01
Overview
Zinc finger protein 253 is a member of the zinc finger protein family, characterized by the presence of Cys2His2-type zinc finger motifs that mediate binding to specific DNA sequences. It is predicted to enable DNA-binding transcription factor activity, specifically RNA polymerase II cis-regulatory region sequence-specific DNA binding, and appears to be involved in the regulation of DNA-templated transcription. Some functional evidence also suggests transcriptional repression activity. The protein is predominantly localized in the nucleus. ZNF253 has been associated with rare genetic conditions such as hypertrichosis universalis congenita, Ambras type. There are no well-established disease roles beyond gene-disease associations, nor known drug interactions or established biomarker applications for this target at present[2][6][7].
- Other names
- BMZF1ZNF411BMZF-1FLJ90391Bone marrow zinc finger 1Zinc finger protein 411DNA-binding protein
02
Biological functions
Regulation of DNA-templated transcriptionTranscriptional repressionDNA recognitionPotential roles in RNA packaging and apoptosis (ascribed to zinc finger protein family)
03
Disease associations
Hypertrichosis universalis congenita, Ambras type
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