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Zinc finger protein 260 (ZNF260)
- Target
- ZNF260
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc finger protein
01
Overview
Zinc finger protein 260 (ZNF260) is a C2H2-type zinc finger transcription factor predicted to enable DNA-binding, especially targeting promoter regions for RNA polymerase II-driven transcription, and acts as a cofactor—particularly in cardiac tissue, where it functions as an effector in alpha1-adrenergic signaling and can cooperatively activate genes such as ANF/NPPA with GATA4, a cardiac regulator[1]. It is primarily localized in the cytosol and nucleoplasm and belongs to the broader family of zinc finger transcription factors, which are widely involved in sequence-specific DNA binding and modulation of gene expression[1][3]. There is no evidence from the search results that ZNF260 is currently a therapeutic target, nor are there known interacting drugs or disease roles directly attributed to this protein[1].
- Other names
- ZFP260Zfp-260ozrf1Zfp260OZRF1PEX1zfp-260
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA bindingCardiac gene expression modulation
03
Disease associations
Other (no direct evidence of implication in specific diseases from the primary search results)
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