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Zinc finger protein 263 (ZNF263)
- Target
- ZNF263
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc finger protein
01
Overview
Zinc finger protein 263 (ZNF263) is a C2H2-type zinc finger transcription factor encoded by the ZNF263 gene in humans. This protein binds specific DNA motifs, acting primarily as a transcriptional repressor. ZNF263 is upregulated in several tumor types, including colorectal cancer, hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer, where it plays a central role in promoting tumor growth, invasion, metastasis, and resistance to apoptosis. It also influences epithelial-mesenchymal transition and regulates STAT3 signaling, linking it to cancer progression, drug resistance, and poor therapeutic response. ZNF263 harbors characteristic C2H2-type zinc finger motifs, enabling sequence-specific DNA binding. High ZNF263 expression may have value as a biomarker for aggressive forms of cancer and for predicting response to targeted therapies in oncology.
- Other names
- ZNF263FPM315ZKSCAN12ZSCAN44
02
Mechanism of action
Transcriptional repression (binds specific DNA motifs and represses transcription); interacts with co-factors, modulates STAT3 expression and stability
03
Biological functions
Transcriptional repressionTranscription regulationCell proliferationEpithelial-mesenchymal transitionApoptosis resistance
04
Disease associations
Cancercolorectal cancerhepatocellular carcinomanon-small cell lung cancerglioblastomakidney cancerpancreatic cancer
05
Safety considerations
Oncogenic potential (promotes cancer progression, metastasis, drug resistance)possible therapeutic resistance
06
Biomarkers
High ZNF263 expression is a potential biomarker for cancer progression and therapeutic response, notably in colorectal cancer and lung adenocarcinoma
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